Yes, you can donate them and convert them to cash donations for most.
Last night I was able to donate out of 2 hotel point accounts, and bank points.
If you, like me, have racked some up — please consider using some to help those recovering from Superstorm Sandy. It won’t dent your pocketbook if you use points, and it could help others greatly. And some are doubling your donation — Starpoints amongst them. If you hook over to donate from your Hilton Honors account, they’re giving you points for donating and matching donations.